Dendritic cells and tolerance induction

Dendritic Cells in Transplant Tolerance

Dendritic cells (DCs) are a heterogeneous family of professional APCs involved in priming adaptive immune responses. Donor DCs (direct pathway of allorecognition) and recipient DCs presenting processed donor major histocompatibility complex (MHC) as peptides (indirect pathway of allorecognition) participate actively in graft rejection by stimulating recipient T cell responses following organ tr...

Modulation of Dendritic Cells for Tolerance Induction*

Dendritic cells (DC) are uniquely well-equipped antigen (Ag) presenting cells that initiate and regulate immune responses. DC play a dualistic role in the regulation of immune responses. They initiate adaptive immunity by the activating naive lymphocytes and are powerful stimulators of natural killer cells – the crucial cellular instigators of the innate immune system. Furthermore, DC induce ce...

Induction by RelB-Silenced Dendritic Cells Immune Modulation and Tolerance

dendritic cells in transplant tolerance

dendritic cells (dcs) are a heterogeneous family of professional apcs involved in priming adaptive immune responses. donor dcs (direct pathway of allorecognition) and recipient dcs presenting processed donor major histocompatibility complex (mhc) as peptides (indirect pathway of allorecognition) participate actively in graft rejection by stimulating recipient t cell responses following organ tr...

Therapeutic Potential of Semi-Mature Dendritic Cells for Tolerance Induction

Dendritic cells (DCs) are major players in the control of adaptive tolerance and immunity. Therefore, their specific generation and adoptive transfer into patients or their in vivo targeting is attractive for clinical applications. While injections of mature immunogenic DCs are tested in clinical trials, tolerogenic DCs still are awaiting this step. Besides the tolerogenic potential of immature...